poria cocos polysaccharide

Notes: None found. Lee et al (2003) Polysaccharide isolated from Poria cocos sclerotium induces NF-κB/Rel activation and iNOS expression in murine macrophages. Studies have evidenced that Poria cocos polysaccharides play a vital role in human health, including antioxidant, anticancer, anti-inflammatory, immunomodulation, antivirals . poria cocos polysaccharide offered on the site come in multiple forms such as capsules, powders, and tablets to suit the needs of children and adults alike. 2. 1. Health Benefits of Poria Cocos Extract Polysaccharides For thousands of years, poria has been used in traditional Chinese and Japanese medicines for its diuretic, sedative, and tonic effects. Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. Byrav D S P, Medhi B, Prakash A, Chakrabarti A, Vaiphei K, Khanduja KL. Effect of molecular mass on antitumor activity of heteropolysaccharide from Poria cocos. In 2015, "Polysaccharidum of Poria cocos oral solution" was approved as a drug by Chinese Food and Drug Administration (SFDA) for treating multiple types of cancers, hepatitis, and other diseases alone or during chemo- or radiation therapy for cancer patients. COVID-19 is an emerging, rapidly evolving situation. Epub 2019 Jan 7. poria cocos polysaccharide Search Trop Picture . We hypothesized that these mushroom polysaccharides could contribute to health benefits, in part, by modulating gut microbiota (GM). cological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti-inflammation, antioxidation, anti-ageing, antihepatitis, antidiabetics and anti-haemorrhagic fever effects. USA.gov. Please share your Comments. Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Wang et al showed that CMP could enhance the tumour inhibition rate of 5‐FU and decrease the liver injuries simultaneously caused by 5‐FU in CT26 tumour‐bearing mice.72. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Poria cocos is a both medicinal and edible Chinese herb variety, with the effects of diuretic, spleen-enhancing and tranquilizing. A wide variety of poria cocos extract polysaccharides options are available to you, such as drum, bottle, and vacuum packed. 9(11): p. 5936-5949. Both advantages and disadvantages of PCPs as drugs rely on their complicated polysaccharide structure‐dependent immune regulatory functions. NLM Poria Cocos Polysaccharide Official CosIng Information. It is a kind of edible and pharmaceutical mushroom. Alibaba.com offers 460 poria cocos extract polysaccharides products. It is specially rich in polysaccharides and triterpene derivatives. The bioactive properties in P. cocos constituents include polysaccharides, triterpenoids, fatty acid s, sterols and enzymes. This site needs JavaScript to work properly. Please check your email for instructions on resetting your password. Poria cocos has tranquilizing, diuretic, and cardiotonic effects. P. cocos polysaccharide(PCP) is one of the most important active substances of P. cocos.  |  Liu X (1), Yu X , Xu X , Zhang X , Zhang X . It is reported by Chen et al69 that the mice moves freely, no abnormal reaction is observed when CMP is used during standard acute toxicity test. The results showed that CMP33 markedly ameliorated the severity of colitis, including a 2-fold decrease in the mortality rate, a 50% decrease in disease activity index, and a 36%-44% decrease in macro- or microscopic histopathological score, compared with TNBS administration. 24-trien-21-oic acid, chitin, protein, fat, glucose, sterols, lecithin, gum, choline, etc. Edible mushrooms and herbal mushrooms: Edible shiitake mushrooms, herbal maitake mushrooms, edible maitake mushrooms, edible brazil mushrooms, edible monkey mushrooms, edible enoki mushrooms, edible morel mushrooms, edible Chantrelle mushrooms, herbal reishi mushrooms, herbal morel mushrooms, herbal nameko mushrooms, herbal monkey head mushrooms etc 12(4): p. 223-7. By integrative analysis of proteomics and metabolomics, key protein-metabolite pathways (PMP) were identified, PMP for high-dose: 2-hydroxybutyric acid - (GPT, GGH) - glutathione - ALB - testosterone - TTR - dihydrotestosterone; PMP for low-dose: (PYY, FABP2, HMGCS2) - oleic acid - TTR - dihydrotestosterone. No toxic reaction is witnessed when the dogs are continuously injected by intravenous injection reported by Ye et al70 They further demonstrated that blood pressure, heart rate, electrocardiogram and breathy of dogs are not affected after intravenously injecting either 400 mg/kg or 800 mg/kg CMP. In consistent, Chai et al71 reported that CMP has no adverse effects on mice as well. In addition, how to standardize the quality of PCPs, especially the degree of chemical modifications of pachymaran derivatives and how to perform reliable pharmacokinetic studies of PCPs are some of important issues to be solved in near future to make use of PCPs for treating patients with cancer worldwide. HHS Hou et al observed that PCP reduces the size of granuloma.56 As an anti‐ageing reagent, PCPs enhance the activities of both T‐SOD and Cu‐SOD and reduce MAD and MAO (monoamine oxidase) activities.57 To understand the antihepatitis effects of CMP, it is found that CMP reduces the expression of HBsAg and HBeAg in a concentration‐dependent manner.58 Zheng et al reported that PCP could reduce blood glucose level and increase the weight of mice in a diabetic mouse model.60 Meanwhile, CMP significantly improves the survival rates of mice suffering acute lymphoblastic leukaemia or ALL.61. Polysaccharides. 9. Thus, there is a great need for clarifying the active ingredients in PCPs besides β‐glucan/pachymaran and their molecular targets responsible for their drug effects. Poria cocos polysaccharide (PCP), extracted from Poria cocos sclerotium, has many biological activities. In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy. It is a purified fraction obtained from "poria cocos (schwein.) The broad spectrum of therapeutic properties, relatively low toxicity and low costs make PCPs attractive immune therapeutics for treating not only different types of cancers but also hepatitis B and other diseases. All authors have approved the final article. PCPs exert their antitumour activity via assisting the host to overcome adverse biological stresses, to assist the host to enhance the lethality of macrophages, T cells, B cells and NK cells by releasing cytokines to increase immunity, and to promote the apoptosis of tumour cells directly by up‐regulating the expression of apoptosis‐related genes, I have read and accept the Wiley Online Library Terms and Conditions of Use, Mycology, cultivation, traditional uses, phytochemistry and pharmacology of, Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of, Studies on the fractionation, structure analysis and bioactivities of Poria cocos acidic polysaccharides, Sulfation of pachyman with chlorosulfonic acid using the improved Wolfrom method, Effect of culture media on the chemical and physical characteristics of polysaccharides isolated from, Antitumour polysaccharide derived chemically from natural glucan (pachyman), Carboxymethylpachymaran, a new water soluble polysaccharide with marked antitumour activity, Solution properties of (1→3)‐α‐D‐glucan and its sulfated derivative from, Immunopotentiation and anti‐tumor activity of carboxymethylated‐sulfated β‐(1→3)‐d‐glucan from, Correlation of structure to antitumor activities of five derivatives of a β‐glucan from, Antitumor effects and pharmacological research of pachymaran, Chinese FDA approved fungal glycan‐based drugs: an overview of structures, mechanisms and clinical related studies, The preparation and study on pharmacodynamics of antitumor of carboxymethy pachymaran, The structure and biological activity of Poria cocos sclerotium polysaccharide and its derivatives, Antitumor function and mechanism study of modified pachymaran, The preparation of water‐soluble pachymaran and the study of its antitumor activities, Studies on antitumor effects and mechanisms of Chinese medicine polysaccharide in signal transduction pathway, Histological observation on antitumor effect of, Antitumor experiments of carboxymethyl pachymaran, The antitumor activities and immune effects of carboxymethyl pachymaran, Studies on immune function and antitumor effect of carboxymethyl pachymaran oral liquid, The preparation and anti‐tumor effect of sulfonyl pachymaran, The effects of pachymaran on immune function in normal and tumor‐burdened mice, The antitumor and related pharmacological effects of pachymaran, The effects of botanical polysaccharides on the proliferation of S180 and K562 cells and the levels of sialic acid, phospholipid and cholesterol, The antitumor effects of pachymaran after chemotherapy, The antitumor and immune effects of compound fungal polysaccharides, The preparation and antitumor effect of carboxymethy pachymaran in vivo, The effects of carboxymethyl pachymaran on increasing lymphocyte induce cytokines, The effects of carboxymethyl pachymaran on phagocytizing function of macrophages, Effects of two fungal polysaccharides on protein tyrosine phosphorylation of HL‐60 cells, The application of carboxymethylpachymaran‐inducers, Growth‐inhibitory effects of a β‐glucan from the mycelium of, Immunomodulatory effect of the polysaccharide‐rich fraction from sclerotium of medicinal mushroom, β (1→3) Glucan‐mediated augmentation of alloreactive murine cytotoxic T‐lymphocytes in vivo, The effects of carboxymethyl pachymaran on lymphocyte secreting cytokines in mice, Inhibition of spontaneous lung metastasis of pachymaran on Lewis lung cancer in mice and its mechanism, The preliminary research on the pharmacological effects of sulfation pachymaran, The effects of pachymaran on the biosynthesis of IgA, IgG and IgM in serum in mice, The effects of pachymaran on humoral immunity function in immunosuppressive mice caused of cyclophosphamide, Pachyman treatment improves CD4 + CD25 +  Treg counts and serum interleukin 4 and interferon γ levels in a mouse model of Kawasaki disease, The response surface method to optimize pachymaran extraction technology and research on its antioxidant activity, Studies on the antioxidative activities of pachymaran, Studies on the antioxidative activities of ferulic acid pachymaran, Studies on the antioxidative activities of carboxymethyl pachymaran, Studies on the anti‐inflammatory effects of pachymaran, Studies on the anti‐aging effects of pachymaran, Studies on carboxymethyl pachymaran on the impact of HBV transfection cells expressing function, The application of Chinese medicine effective component in interferon biotechnology experiment and clinical research, Studies on the anti‐diabetic effects of pachymaran, Studies on the anti‐leukemia effects of pachymaran combined with selenium in mice, Studies on antinephritic effects of plant components (3): effect of pachyman, a main component of, Synthesis and antihypertensive activity of pachyman sulfate, The clinical trials of carboxymethyl pachymaran inducers, Experimental and clinical studies on carboxymethyl pachymaran on promoting the induction of IL‐2, The medical function of carboxymethyl pachymaran, The observations of pachymaran on the cell immune function of patients with lung cancer and clinical curative effects, The effects of pachymaran on immune function of tumor‐burdened mice, the elderly and patients with tumor, Carboxymethyl tuckahoe polysaccharide the safety of the experiment, Toxicity studies on sodium carboxymethyl pachymaran, Pharmacological effects and toxicity about carboxymethyl pachymaran, Hepatoprotective effect of carboxymethyl pachyman in fluorouracil‐treated CT26‐bearing mice, Journal of Cellular and Molecular Medicine, Hericium erinaceus polysaccharide+Lentinan+Pachymaran, Agaricus blazei murill polysaccharide+Lentinan+CMP, 1,1‐Diphenyl‐2‐picrylhydrazyl radical 2,2‐Diphenyl‐1‐(2,4,6‐trinitrophenyl)hydrazyl, Polysaccharide extracted using 0.5 mol/L NaOH, Polysaccharide extracted using 88% formic acid, Phosphorylation of protein tyrosine phosphatase, CMP‐induced IFN‐α+ Traditional Chinese medicine, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu + CMP‐induced IL‐2, Mitomycin/cis‐platinum/doxorubicin/5‐Fu + CMP‐induced IL‐2, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu+ CMP‐induced IFN‐α, Mitomycin/cis‐platinum/pharmorubicin/5‐Fu+ PCP. Main chemical constituents of Poria cocos includes: beta-pachyman, a polysaccharide beta-pachymarose, several organic acids such as tumulosic acid, eubricoic acid, pinicolic acid, and pachymic acid, 3-beta-hydroxylanosta-7,9(11). PMID: 15784995; Jin Y, Zhang L, Zhang M, Chen L, Cheung PC, Oi VE, Lin Y. Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media. IFN‐α was obtained from human peripheral blood lymphocytes treated with CMP. Poria cocos polysaccharide (PCP) was extracted from the dried sclerotium of Poria cocos (84%, w/w), (Li X. et al., 2019) ().Different crude polysaccharide fractions were isolated by different solvent extraction methods, such as PCM1 (0.9% NaCl), PCM2 (hot water), PCSIII-2 (0.5 mol/L NaOH), PCM0 (MeOH), and PCP4-II (88% formic acid) (Wang et al., 2004a). As a result, "Poria cocos polysaccharide oral solution" was developed and sold as an over-the-counter health supplement since 1970s. Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation. Poria cocos extract has the effects of protecting livers, lowering the enzyme, prolonging the life. In this article, the structure, pharmacological effects, clinical efficacy, immunobalancing molecular mechanism and toxicity of PCPs are summarized in Figures 1-5 and Tables 1-8. NIH Poria Cocos or the Fu Ling Mushroom is a mushroom that stems from the traditional Chinese medicine. Seven clinical studies on PCPs were found through literature search.59, 64-68 The clinical data are summarized in Table 8. Sorteren. PCP down-regulated phosphorylation of STAT3, 32 ERK and JNK, and thus repressed the expression of NFAcT1 and c-Fos during RANKL-induced Poria cocos (P. cocos), called Fuling, Tuckahoe, Hoelen, or Indian bread, is an edible fungus commonly found on dead bark and roots of pine trees in China, Korea, Japan, and North America.As reported previously, it contains a wide variety of constituents, including triterpenes, 1 polysaccharides, 2 steroids, 1 and various small-molecule constituents. 2020 Sep 7;26(33):4889-4899. doi: 10.3748/wjg.v26.i33.4889. In total, these results demonstrated the protective effects of CMP33 against IBD in mice through the potential TPG and PMP. In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. World J Gastroenterol. Andere namen: Tuckahoe, Indian bread, hoelen (Engels), Poria cocos (Duits), Pachyme (Frans) Actieve componenten: polysacchariden, ergosterol, fungisterol, choline, fosfolipiden, natrium, kalium, calcium, magnesium, ijzer, mangaan, zink, koper Deze paddenstoel lijkt qua vorm op een kleine kokosnoot, vandaar de naamgeving cocos (kokos). 20. Dermalogica Biolumin-C Eye Serum Juhldahl Facecream No 6. Particularly, some targeting proteins were CMP33-dose-specific: high-dose-specific TPG (Mtco3, Gal-6, Mptx, S100 g and Hpx) and low-dose-specific TPG (Zg16, Hexb, Insl5, Cept1, Hspb6 and Ifi27l2b), suggesting the complex acting mechanism of CMP33. and you may need to create a new Wiley Online Library account. Epub 2014 Nov 10. Int J Biol Macromol. About 60% of these are herbal extract, 6% are mushroom extract, and 1% are fruit extract. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-α and IL-1β). It proved to be as highly effective as well as energy and time saving extraction techniques. Most of studies are related to the antitumour effects of CMP where these studies use IL‐2 or IFN‐α obtained from human peripheral blood lymphocytes induced by CMP in combination with chemotherapy or radiotherapy. Epub 2018 Nov 15. The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Skin Res Technol, 2006. Great advances have been made in chemical and bioactive studies on Poria cocos polysaccharides (PCP) and their derivatives in recent decades. Prevention and treatment information (HHS). Food Funct, 2018. The chemical compositions of Poria cocos mainly include triterpenes, polysaccharides, steroids, amino acids, choline, histidine, etc. Please enable it to take advantage of the complete set of features! All grants and funding agencies play no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. This research was supported by Natural Science Foundation of China (Grant No. 24-trien-21-oic acid, chitin, protein, fat, glucose, sterols, lecithin, gum, choline, etc. eCollection 2020. Karrout Y, Dubuquoy L, Piveteau C, Siepmann F, Moussa E, Wils D, Beghyn T, Neut C, Flament MP, Guerin-Deremaux L, Dubreuil L, Deprez B, Desreumaux P, Siepmann J. J Control Release. IL‐2 and IFN‐α were obtained from human peripheral blood lymphocytes treated with CMP. Applications Of Poria Cocos Extract. High purity polysaccharide of pachyman was isolated from the powder of Poria cocos sclerotium with an yield of 77.8%. In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. Email Address: 2019 Apr 15;127:39-47. doi: 10.1016/j.ijbiomac.2019.01.029. Purification, antitumor and anti-inflammation activities of an alkali-soluble and carboxymethyl polysaccharide CMP33 from Poria cocos. Moreover, CMP33 decreased the levels of pro-inflammatory cytokines and increased the levels of anti-inflammatory cytokines in the colon tissue and serum of colitic mice. No teratogenic effects are detected on rats when CMP is used in the teratogenic tests. polysaccharide remained 4.14%. Articles: None found yet. Clipboard, Search History, and several other advanced features are temporarily unavailable. The present study explored the immunomodulatory effect and the underlying molecular mechanism of PCP in RAW 264.7 macrophages. The poria cocos polysaccharide are available in a wide variety that considers different factors and requirements for individuals and groups of people. Among them, 7 proteins (Hmgcs2, Fabp2, Hp, B4galnt2, B3gnt6, Sap and Ca1) were proposed to be the common targeting protein group (TPG) of CMP33 and drug SASP. De Poria paddestoel heeft een brede samenstelling aan nutrienten en werkzame stoffen. Using iTRAQ-coupled- nano-HPLC-MS/MS-based proteomics, the protein profiles after TNBS, high- or low-dose CMP33 and salazosulfapyridine (SASP) treatments were compared and many differentially expressed proteins were identified. 81672585); Key Technology Fund of Shandong Province (Grant 2016ZDJS07A07); and the “Double First‐Class” fund of Shandong Province to LZ. The main active components are water-soluble polysaccharides (WPS) and triterpenoids. 2020 Sep 15;11:505249. doi: 10.3389/fphar.2020.505249. Although few scientific studies have looked at the health effects of poria, some preliminary research shows that it may protect against certain conditions. NCI CPTC Antibody Characterization Program. CMP has very low toxicity. Pharmacol Rep. 2013;65(4):951-9. doi: 10.1016/s1734-1140(13)71076-4. OH radical‐scavenging activity in vitro.54, 55 Superoxide dismutase (SOD) is an important antioxidant enzyme in organisms and Chen et al showed that CMP could increase the expression of SOD and reduce the amount of MAD (malondialdehyde).53, PCPs have other biological effects, such as anti‐inflammatory,56 anti‐ageing,57 antihepatitis,58, 59 antidiabetic,60 anti‐ALL (acute lymphoblastic leukaemia),61 anti‐nephritic62 and antihypertensive effects.63 These pharmacological activities are summarized in Table 7A,B. Poria cocos has tranquilizing, diuretic, and cardiotonic effects. Try the PubMed Search. Optimization of Bioprocess Extraction of Poria cocos Polysaccharide (PCP) with Aspergillus niger -Glucanase and the Evaluation of PCP Antioxidant Property Peng Wu 1, Hongyuan Tan 1, Jianfeng Zhan 1, Weixin Wang 1, Ting Hu 1,* and Shiming Li 1,2,* 1 Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Int Immunopharmacol 3(10–11):1353–1362 CrossRef Google Scholar. 2016 Nov 4;192:309-319. doi: 10.1016/j.jep.2016.07.056. Vind de fabrikant Natuurlijke Poria Extract Polysaccharide van hoge kwaliteit Natuurlijke Poria Extract Polysaccharide, leverancier en producten voor de laagste prijzen bij Alibaba.com The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Poria cocos, an important medicinal and edible fungus, is well known in East Asia.  |  Positie asc. Nie A, Chao Y, Zhang X, Jia W, Zhou Z, Zhu C. Front Pharmacol. 29 anti-inflammatory effect and found that poria cocos polysaccharide (PCP) inhibited 30 RANKL-induced osteoclast formation and bone resorption via TRAcP staining, 31 immunofluorescence, RT-PCR and western blot. GLADBACK™ by Provital acts as a firming, anti-oxidant, purifying and anti-wrinkle agent. The authors declare no conflict of interests. Due to the growing market demand, long cultivation period, and consumption of pine trunk during cultivation, alternative methods for producing P. cocos or its active components should be investigated.

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