It is the disturbance of the blood clotting mechanism. Coagulation defects in pregnancy 1.
Pathology Seminar October 2010 Year 4 MedicineGroup 1 UST Sana’a 2. This topic will focus on DIC related to pregnancy. Obstetrical disseminated intravascular coagulation (DIC) is usually a very acute, serious complication of pregnancy. Coagulation Defects in Pregnancy
2. The DIC diagnostic criteria in obstetrics (the obstetrical DIC score) help with making a prompt diagnosis and starting treatment early. Broader discussions of the pathogenesis, clinical manifestations, diagnosis, and treatment of DIC … The incidence of DIC in pregnancy varies and is dependent on the underlying obstetric complication. Introduction DIC stands for Disseminated intravascular coagulation. Pregnancy Thrombin summary As activation of the coagulation pathway is a physiological response to injury, the development of dis-seminated intravascular coagulation (DIC) is a warning signal to the clinician that the primary patholog-ical disease state is decompensating. For example, in cases of complete placental abruption accompanied by intrauterine fetal demise (IUFD) and hemorrhage, DIC is common. DIC Presentation 1. patients with overt DIC had higher mortality than patients without (43% vs. 27%). Even in the setting of fetal demise, labor and vaginal delivery of a pregnant woman with DIC carries the potential for catastrophic hemorrhage. In pregnancy, DIC can occur in several settings, which include 2 In contrast, DIC associated with IUFD without placental abruption is quite rare except when products of conception are retained beyond 5 weeks. Activated protein C-treated patients with overt DIC had a greater relative risk reduction in mortality than patients without (29% vs. 18%, P=0.261). In DIC, clot formation is delayed up to 30 seconds (hypofibrinogenaemia) or it will not form at all (afibrinogenaemia).
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